Inclusion of amphipathic PEG as emulsifier into oil-in-water emulsions is a very effective method to prolong the blood half life of the emulsions. Formulation of drug-dosage form as an emulsion. An emulsion is not contained only water and oil it may also contain some solid particles. These drugs are usually poorly soluble in water but readily soluble in oils. pharmaceutical, agricultural, cosmetics, and petroleum 2. Increased drug bioavailability: Many drugs are highly hydrophobic, with high log P values (partition coefficient between oil and water). The activity of PEG derivatives in prolonging the circulation time of emulsions depends on the PEG chain length (PEG2000 > PEG5000 > PEG1000, Tween-80) and the PEG density on emulsion surface. The main advantages of emulsions as drug delivery systems include the following: 1. Inclusion of PEG derivatives such as Tween-80 or dioleoyl N-(monomethoxy-polyethyleneglycol succinyl)phosphotidylethanolamine (PEG-PE) into emulsions composed of Castor oil and phosphatidylcholine decreases the RES uptake and increases blood residence time of the emulsions. Water in oil emulsions have a high potential in cosmetic, biological, pharmaceutical, agricultural, and food industries. The effect of amphipathic PEG on reducing the RES uptake and prolonging the blood circulation of the emulsion particles has been tested in vivo using mice as an animal model.
#WATER IN OIL EMULSION PHARMACY DRUG SERIES#
The purpose of this study therefore is to overcome this problem and develop emulsions that will have prolonged blood circulation time.Ī series of amphipathic polyethylene-glycol (PEG) derivatives have been included as co-emulsifier into emulsions composed of Castor oil and phosphatidylcholine. Emulsion or water-removable bases are oil-in-water (o/w) emulsions. Emulsion or water-removable bases and creams. It contains urea as the active ingredient and is used to help rehydrate dry, scaly skin. Rapid clearance of parenterally administered oil-in-water emulsions from blood by the reticuloendothelial system (RES), mainly macrophages of the liver and spleen, has been one of the major obstacles for delivering lipophilic drugs to cells other than those in the RES. For example, Eucerin cream is a w/o emulsion of petrolatum, mineral oil, mineral wax, wool wax, alcohol, and bronopol.
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